PRF, PRP, Vampire Facial | Facial Aesthetics Split, Croatia

Treatment with your own blood
(Cleopatra's treatment)

PRF is an abbreviation for the term “platelet-rich fibrin,” which means “platelet-enriched fibrin.” PRF has a wide range of indications in dermatology, cosmetics, dentistry, orthopedics, and other medical fields. It is also called “vampire treatment.” It is used to treat various conditions and to rejuvenate the skin.

I-PRF (PRF (Injectable Platelet-Rich Fibrin) is a new method that contains platelet-rich fibrinogen, which is used in liquid form for easier injection. The patient’s blood is centrifuged in tubes without coagulants, so the preparation obtained is 100% natural and is applied to the skin as such. It is a revolutionary process of skin rejuvenation and regeneration using stem cells and growth factors from your own blood. Our blood contains specific growth factors that stimulate the proliferation of fibroblasts and keratinocytes. These cells are involved in the production of collagen and keratin and play an important role in the regeneration of damaged cells and in the creation of new blood vessels, giving rise to young tissue.

The treatment can be combined with different materials such as hyaluronic acid and vitamins. This treatment is called the Cleopatra treatment after Professor Cleopatra Nacopoulos, who developed it.

The treatment is carried out at individual intervals. After just one treatment, an improvement of up to 30% is visible. It is desirable to carry out three treatments. After that, it is recommended to repeat the treatment once a year.

PRF therapy is used for:

PRF therapy is NOT used in the presence of platelet dysfunction, critical thrombocytopenia, hemodynamic instability, autoimmune diseases, sepsis, acute and chronic diseases, pregnancy, chronic liver disease and anticoagulation therapy, active skin infections, active acne, keloid scars.

Preparation and Application

PRF therapy is quick and easy to perform. Before the treatment, doctors take 10 to 20 ml of your blood using a standard procedure. The pain you will feel is minimal and negligible, just like with a classic blood draw. After that, the doctor uses a special technique, that is, a high-speed centrifuge, to separate the plasma from the other components of your blood.

PRF is a relatively quick treatment. Facial cleansing and application of anesthesia (topical or local anesthesia) usually takes 15 to 45 minutes, while the procedure itself takes only 20 to 30 minutes. During the treatment, some people experience micro-bleeding, but this is normal and there is no need to worry.

During the treatment, some people experience microbleeding, but this is normal and nothing to worry about.

Recovery phase

After the procedure, redness, swelling, minimal discomfort in the treated area, bruising, dryness and flaking of the skin may occur.

Most patients return to their normal activities immediately after treatment.

Don’t expect to see a miracle in the mirror the morning after a treatment. After all, collagen doesn’t grow overnight. The first results are visible after a few weeks in terms of moisture, structure and skin tone. The actual results are only visible after a few months, while the full effect is expected for up to two years. After the age of 20, collagen production decreases by 1% annually. Without enough collagen, the skin loses shape and wrinkles appear. Collagen is lost more quickly due to injuries such as acne scars, stretch marks or other scars. During this period after treatment, the skin is revitalized, becomes softer, more elastic and visibly rejuvenates. Over time, wrinkles become less noticeable, scars and stretch marks slowly fade and the skin looks increasingly brighter. It is important to understand that it may take several months to see all the results of the procedure.

Precautionary measures

PRF stem cell rejuvenation therapy is a simple and safe treatment. Since PRP is extracted from your blood, there is no possibility of transmitting diseases, allergies or immune reactions. PRP therapy is not used when there is platelet dysfunction, critical thrombocytopenia, hemodynamic instability, autoimmune diseases, sepsis, acute and chronic diseases, pregnancy, chronic liver disease and anticoagulation therapy,

PRP therapy is not used when there is platelet dysfunction, critical thrombocytopenia, hemodynamic instability, autoimmune diseases, sepsis, acute and chronic diseases, pregnancy, chronic liver disease and anticoagulation therapy.

Chemical Peels

Chemical peels are procedures that involve the application of chemical solutions to the skin in order to exfoliate the thickened surface layer and stimulate collagen production. They are used to treat various skin concerns such as acne, pigmentation, acne scars, fine lines and wrinkles, and hyperpigmentation. An ideal candidate is anyone looking to improve skin texture and hydration, achieve a more youthful appearance, reduce wrinkles, or correct pigmentation issues.

Benefits of chemical peels:

A few key aspects of chemical peels

Types of Peels

There are different types of chemical peels, including superficial, medium-depth, and deep peels. Superficial peels target the outer skin layer (epidermis), medium-depth peels penetrate deeper (into the mid-layer of the skin – dermis), while deep peels reach the lower dermal layers.

Results

Skin improvement and rejuvenation occur gradually and appear completely natural. Final results are visible a few weeks after the last performed peel.

Side Effects

As with any cosmetic procedure, chemical peels may have side effects such as redness, irritation, peeling, and increased sun sensitivity. It is important to follow medical instructions and protect the skin adequately from sun exposure after the treatment.

BOTULIN

Botulin Treatment is a cosmetic procedure that uses botulinum toxin to temporarily relax muscles and reduce facial wrinkles. It is commonly used to treat forehead lines, crow’s feet (wrinkles around the eyes), and frown lines between the eyebrows. Here are some basic facts about Botulin treatment:

How it works: Botulin blocks signals between nerves and muscles, preventing the muscles from contracting. This reduces the appearance of wrinkles and fine lines.
The procedure: The treatment is done in-office and takes only a few minutes, with results becoming visible within a few days. This speed makes Botox an excellent option for people with busy schedules who can’t commit to lengthy procedures.
Results: In addition to softening existing wrinkles, Botulin
can help prevent new ones from forming. Regular treatments can reduce the depth and visibility of wrinkles over time, maintaining a youthful appearance. Results typically appear within a few days and last about 3–6 months, depending on the amount of Botulin injected and the individual’s muscle activity. After that period, muscle movement gradually returns, and wrinkles may reappear.
Safety: Botulin is safe when administered by licensed and experienced medical professionals. Side effects are rare but may include temporary muscle weakness, bruising, or headaches.
Recovery time: Botulin treatments usually require minimal downtime.

BABY BOTULIN

Treatments known as “baby Botulin” offer a subtle and natural-looking facial appearance. This option is especially popular among younger clients who want to maintain natural facial expressions. Baby Botulin allows the benefits of Botulin while preserving a natural look, which further contributes to its growing popularity.

Lip Augmentation

Lip Augmentation

Lip enhancement is arguably the most popular aesthetic treatment.

Lips have always been considered one of the most attractive and sensual features of the female body and are among the first things people notice. Beautiful, full, and well-defined lips are a symbol of youth and femininity. However, as we age, our lips tend to become thinner and flatter over time.

How is lip augmentation and shaping performed?

Lip augmentation and shaping are performed using dermal fillers based on hyaluronic acid — a natural component of the skin. The filler is injected along the lip border and into the lips themselves to achieve the desired shape and volume.
There are various injection techniques used to create different effects, depending on the client’s preferences and the best possible outcome. In addition to the lips, attention should also be paid to perioral wrinkles, lip corners, and lines in the lip corners to ensure a harmonious facial appearance. The treatment is performed differently on younger and older individuals.

It is better to start with a smaller amount that can be topped up later, rather than insisting on excessive filler volume, which ultimately does not result in an attractive look.

Does lip augmentation hurt?

We use various products and techniques to numb the area where dermal fillers are injected. The procedure begins only when the lips are fully desensitized to needle pricks.

Side effects of lip augmentation?

Initially, the lips may be swollen and slightly bruised, but these symptoms typically disappear or are significantly reduced within 48 hours after the procedure.

How long does the effect of lip fillers last?

If you’re getting lip augmentation for the first time, the effect typically lasts up to 6 months (shorter if you’re a smoker).
However, with subsequent treatments, the effects usually last between 9 months and 1 year.

NEOFOUND WHITENING

What is Neofound?

Neofound is a biorevitalizing solution specifically indicated for cases of skin discoloration.

The special formulation NEOFOUND WHITENING combines ingredients with a biostimulating effect (such as hyaluronic acid of various molecular weights and amino acids) with those capable of modulating melanin production at different levels.

After a long and hot summer, our skin often suffers the consequences of exposure to sun, wind, salt, and high temperatures. While sun exposure brings a bronzed glow, it can also lead to dehydration, fine lines, pigmentation spots, and loss of skin elasticity. This is the perfect time for **facial biorevitalization**, a treatment that refreshes, hydrates, and restores the skin’s natural glow.

What is Biorevitalization?

Biorevitalization is a non-invasive aesthetic procedure that involves injecting hyaluronic acid and other nourishing ingredients directly into the skin. This treatment deeply hydrates the skin, stimulates cell regeneration, and restores lost radiance and elasticity.

Why choose biorevitalization after summer?

Deep hydration: The hyaluronic acid used in the treatment binds water and restores necessary moisture, making the skin smooth and soft.
Skin regeneration: The treatment stimulates natural collagen production, helping reduce wrinkles and improve skin elasticity.
Reduction of pigmentation: Ingredients in biorevitalization help fade dark spots and even out skin tone.

Neofound is effective for:

Sunspots and age spots
Post-inflammatory hyperpigmentation
Melasma and chloasma
Dull and inelastic skin

When are results visible?

Results can be seen after just one session. For optimal outcomes, a series of 3 treatments spaced 2 weeks apart is recommended.

EXOSOMES

What Are Exosomes?

Exosomes are microscopic extracellular vesicles ranging from 30 to 100 nanometers in diameter, secreted by cells from various tissues and organs into the intercellular space. They circulate through the body via the bloodstream. Inside these vesicles is a “cocktail” of proteins, DNA, various types of RNA, growth factors, and lipids.

How Do Exosome Treatments Work?

Exosome treatments are suitable for all skin types. They have anti-inflammatory properties, stimulate collagen synthesis, strengthen the skin barrier, repair the skin, reduce wrinkles, scars, and pores, improve skin firmness, and help lighten hyperpigmentation. Exosomes play a key role in cellular regeneration and stimulate internal hydration, resulting in rejuvenated, healthy, and youthful-looking skin. They also participate in the transfer of signaling molecules between cells and help remove cellular waste and toxic proteins.

Exosome therapy is one of the most popular rejuvenation methods used in regenerative medicine. At our clinic, we use the JeuDerm brand (Rejusome product) with an injectable technique, ideal for treatments on the face, neck, and décolletage.

Effects of Exosomes:

Anti-inflammatory action
Stimulate collagen production
Strengthen the skin barrier
Skin regeneration
Reduce wrinkles, scars, and enlarged pores
Improve skin tone and firmness
Lighten hyperpigmentation
Control transepidermal water loss
Provide a powerful anti-aging effect

When Are Results Visible?

Results are noticeable after just one session, but for optimal outcomes, a series of 3 treatments spaced 2 weeks apart is recommended.

SUNEKOS

What is Sunekos?

Sunekos biostimulators are innovative anti-aging treatments in aesthetic medicine, designed to naturally enhance the skin’s appearance. Their effectiveness is based on the stimulation of elastin, collagen, and fibronectin production, contributing to the reconstruction of the extracellular matrix (ECM). These biostimulators not only reduce the signs of aging, but also produce natural-looking results—leaving the skin smooth, hydrated, and radiant. The treatment provides both instant results (thanks to hyaluronic acid) and long-term effects that last longer compared to many other treatments.

Sunekos consists of non-crosslinked hyaluronic acid combined with six selected amino acids that stimulate the production of type IV and VII collagen, which are essential for healthy skin. Our clinic uses two formulations: Sunekos 1200 and Sunekos Performa, each containing hyaluronic acid of different molecular weights. In addition to improving elasticity, volume, and hydration, Sunekos also reduces wrinkles and dark under-eye circles, improves skin tone, and has anti-inflammatory properties.

How Does the Sunekos Treatment Work?

This treatment is suitable for all age groups and can be applied to the face, neck, décolletage, hands, as well as for treating stretch marks and cellulite. It is ideal for individuals seeking a natural skin enhancement, a more even skin tone, and reduced visibility of hyperpigmentation or scars.

Effects of Sunekos:

Improves skin elasticity, volume, and hydration
Stimulates collagen synthesis
Reduces wrinkles and dark circles
Enhances skin tone
Provides anti-inflammatory benefits

When Are Results Visible?

Results can be seen after the first session, but for optimal results, a series of 3 treatments every 2 weeks is recommended. The effects are long-lasting, typically 8 months to 1 year, after which booster doses are advised for maintenance.

The treatment takes about 15 minutes, is virtually painless, and patients can return to their daily routine almost immediately. During the first session, 2 formulations are administered, followed by 1 per session in the next two cycles.

Jeu Derm CRYSTAL PDRN Polynucleotides

What Are Polynucleotides?

Polynucleotides are essentially fragments of DNA—complex chains of nucleotides that serve as fundamental building blocks of cells and play a key role in various biological processes, including repair, regeneration, and cell renewal. They interact with fibroblasts—connective tissue cells—which recognize them and begin to divide more rapidly, resulting in stronger and more resilient skin. These DNA fragments not only stimulate skin regeneration but also provide intense hydration, restore lost volume, and reinforce skin structure.

Polynucleotide treatments are particularly suitable for women (and men) seeking subtle, natural improvements without drastic changes to facial contours. Instead, the goal of the treatment is to restore former elasticity and skin tone, naturally rejuvenating the face.

How Does the Crystal PDRN Treatment Work?

These treatments are performed via injection, delivering hyaluronic acid, polynucleotides, vitamins, and minerals directly beneath the skin, ensuring fast and visible results. What makes polynucleotide treatments unique is their deep regenerative capacity. They stimulate natural collagen production, and the skin is renewed at all levels—from the surface to deeper layers. Cellular regeneration begins immediately after treatment, and results continue to improve over time.

Effects of Polynucleotides:

Stimulate cellular regeneration – accelerate the natural renewal process
Boost collagen production – essential for skin firmness and elasticity
Deeply hydrate the skin and restore radiance
Increase fibroblast count – encouraging new connective tissue cell formation
Protect against oxidative stress – neutralize free radicals

When Are Results Visible?

Results are noticeable almost immediately after the treatment—the skin becomes visibly more hydrated, smoother, and firmer, with fine lines reduced. For optimal results, a series of 3 to 5 sessions every 2 weeks is recommended.

The treatment lasts about one hour and requires minimal recovery time, making it an ideal choice for anyone seeking a fast and effective skin rejuvenation solution without invasive procedures.

JEU DERM POLYCAPROLACTONE ULTRA V LIFT

What is Ultra V Lift?

ULTRA V is a unique liquid biostimulator based on polycaprolactone (PCL), a high-tech, biocompatible, and biodegradable polymer that accelerates stem cell regeneration and collagen synthesis (collagenesis).

How Does the Ultra V Lift Treatment Work?

Ultra V Lift stimulates collagen production and acts as a collagen booster—collagen being essential for maintaining skin firmness and elasticity. It can be used on various areas of the face, including the forehead, cheeks, chin, and lips, making it a versatile treatment.
Unlike other dermal fillers, PCL has the ability to stimulate collagen production long-term, meaning the results of PCL treatments often last longer than with other fillers.

Effects of Ultra V Lift:

Skin lifting and improved tone
Deep skin hydration
Lightening of pigmentation spots
Filling fine lines and preventing new ones
Long-lasting stimulation of type I collagen
Noticeable improvement in skin thickness, density, and elasticity

When Are Results Visible?

Results are almost immediately noticeable after the treatment—skin becomes visibly hydrated, smoother, and firmer, and fine lines are reduced.
For optimal results, a series of 2 treatments spaced one month apart is recommended.

Important: No cosmetic treatments should be performed one month before or after the application of Ultra V Lift.
The effect lasts between 2 and 4 years, and it is recommended once per year for maintenance.

Yaqoot

What is Yaqoot?

Yaqoot is a highly effective next-generation biostimulator designed for deep regeneration of all skin types through an advanced combination of hyaluronic acid and specific amino acids. Its purpose is not only to provide aesthetic benefits but also to functionally improve skin quality by stimulating its natural renewal processes. It is particularly suitable for treating the skin of the face, neck, décolleté, and hands and is used in dermo-aesthetic treatments that do not require invasive procedures.

How does the Yaqoot treatment work?

The Yaqoot biostimulator treatment works on the principle of biorevitalization – it stimulates the skin’s own cells to produce collagen and elastin, leading to improved structure, tone, and elasticity. It is recommended to combine it with other biostimulation treatments as it helps prevent the breakdown of newly formed collagen. Its key features include:

Targeted stimulation of fibroblasts
Restoration of the skin’s natural hydration
Strengthening of the dermal matrix without damaging the epidermis
Non-invasive yet deep action that requires no downtime

The Yaqoot treatment is minimally uncomfortable, quick, and suitable for all skin types, including sensitive skin.

Yaqoot’s Effects

Yaqoot works on multiple levels and provides visible improvements across several aspects:

Restoration of damaged skin and improvement of texture
Reduction of hyperpigmentation and surface irregularities
Minimization of fine lines and loss of volume
Increased skin resistance to external factors such as UV radiation

The treatment restores the skin’s natural glow, healthy tone, and leaves it smooth, radiant, and visibly younger.

When are results visible?

Visible improvements can be noticed as early as 7 to 10 days after treatment, while optimal results develop over the course of 3 to 4 weeks. Ideally, a series of 3 to 4 treatments spaced 10 to 14 days apart is recommended to achieve a long-lasting and stable effect.

Facial aesthetics

Treatment with your own blood
(Cleopatra's treatment)

Treatment with your own blood
(Cleopatra's treatment)